Keywords
Antimalarials
COVID-19
Pre-Exposure
Analysis
How to Cite
Abstract
The aim was to analyze the use of antimalarials in the pre-exposure prophylaxis of COVID-19. This is a literature review, with the approach of analysis of randomized, review and integrative literature reviews. The research was carried out through online access to the PubMed and Google Scholar databases. A total of six articles were used out of a total of 761, selected by different criteria. The articles highlighted the inefficiency of antimalarials, hydroxychloroquine and chloroquine, as a prophylactic measure against pre-exposure to the COVID-19 virus; in addition, they also demonstrated some adverse effects, such as toxicity caused by the continuous use of such drugs. The use of antimalarials has no scientifically proven beneficial effects for the prophylaxis of COVID-19 or its treatment. In this context, the importance of using drugs and other scientifically proven therapeutic or prophylactic procedures for the cause is highlighted.
References
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The lancet. 2020;395(10223):497-506. https://doi.org/10.1016/S0140-6736(20)30183-5
Basch CH, Hillyer GC, Meleo-Erwin ZC, Jaime C, Mohlman J, Basch CE. Preventive Behaviors Conveyed on YouTube to Mitigate Transmission of COVID-19: Cross-Sectional Study. JMIR Public Health Surveill. 2020;6(2):e18807. DOI: 10.2196/18807. Erratum in: JMIR Public Health Surveill. 2020 May 6;6(2):e19601. PMID: 32240096; PMCID: PMC7124952.
Aquino TF, Teixeira Júnior RM, José ESS, Silva JDD. Pandemia de COVID-19: o olhar da população em relação às medidas preventivas. Glob Acad Nurs. 2020;1(3):e43. https://dx.doi.org/10.5935/2675-5602.20200043
Robles-Lessa MM, Dias VED, Silva SM, Cabral AJ, Cabral HLTB. Análise de Hidroxicloroquina e possíveis benefícios no tratamento da COVID-19. Revista Transformar [Internet]. 2020 [acesso em 22 set 2022];14(2):260-282. Disponível em: http://www.fsj.edu.br/transformar/index.php/transformar/article/view/397/194
Weber M. Economia e Sociedade: fundamentos da sociologia compreensiva. 4. ed. Brasília: Editora Universidade de Brasília; 2009.
Batista TAB, Gomes AHD, Bachur TPR. Clinical implications and cardiotoxicity in hydroxychloroquine overdose. Revinter. 2021;14(2):29-35. https://doi.org/10.22280/revintervol14ed2.495
Imperador CHL, Espreafico Junior CR, Antonio MVN, Chin CM, Bosquesi PL. Cloroquina e hidroxicloroquina associado ao zinco e/ou azitromicina na COVID-19. Ulakes Journal of Medicine [Internet]. 2020 [acesso em 22 set 2022];1(Spe.COVID-19). Disponível em: https://revistas.unilago.edu.br/index.php/ulakes/article/view/258
Párraga GCV, Pinduisaca FFC, Laaz SAL, Quinto WPC. Recomendaciones de manejo farmacológico en COVID-19. Recimundo. 2020;4(2):31-39. DOI: 10.26820/recimundo/4.(2).mayo.2020.31-39
Devaux CA, Rolain JM, Colson P, Raoult D. New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19? Int J Antimicrob Agents. 2020;55(5):105938. DOI: 10.1016/j.ijantimicag.2020.105938
Danza A, Díaz L, Ruiz-Irastorza G. Hidroxicloroquina en el embarazo y la lactancia. Revista Médica del Uruguay [Internet]. 2015 [acesso em 22 set 2022];31(2):128-132. Disponível em: http://www.scielo.edu.uy/scielo.php?script=sci_arttext&pid=S1688-03902015000200007
Menezes CR, Sanches C, Chequer FMD. Efetividade e toxicidade da cloroquina e da hidroxicloroquina associada (ou não) à azitromicina para tratamento da COVID-19. O que sabemos até o momento? Journal of Health & Biological Sciences. 2020;8(1):1-9.
Figueiredo BQ de, Cancela BR, Rodrigues AEL, Falcão ALS, Prado DMM do, Rocha D da, Lima IC de M, Silva Segundo RJ e. Analysis of possible intoxications resulting from the indiscriminate use of ivermectin and hydroxychloroquine during the COVID-19 pandemic. RSD [Internet]. 2022Feb.16 [acesso em 22 set 2022];11(3):e14511326441. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/26441
Rajasingham R, Bangdiwala AS, Nicol MR, Skipper CP, Pastick KA, Axelrod M, et al. Hydroxychloroquine as pre-exposure prophylaxis for coronavirus disease 2019 (COVID-19) in healthcare workers: a randomized trial. Clinical Infectious Diseases. 2021;72(11):e835-e843. DOI: 10.1093/cid/ciaa1571
Villar OM, et al. A cluster-randomized trial of hydroxychloroquine for prevention of COVID-19. New England Journal of Medicine. 2021;384(5):417-427. DOI: 10.1056/NEJMoa2021801
Abella BS, Jolkovsky EL, Biney BT, Uspal JE, Hyman MC, Frank I, et al. Efficacy and safety of hydroxychloroquine vs placebo for pre-exposure SARS-CoV-2 prophylaxis among health care workers: a randomized clinical trial. JAMA internal medicine. 2021;181(2):195-202. DOI: 10.1001/jamainternmed.2020.6319
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