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Ozone therapy in COVID-19: an integrative review
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Keywords

Coronavirus Infections
Infection SARS-CoV-2
COVID-19 Virus Infection
Immune System

How to Cite

1.
Jurado SR, Paiz C dos S, Bispo IMGP, Furlan MCR, Bassler TC, Sanchez A. Ozone therapy in COVID-19: an integrative review . Glob Acad Nurs [Internet]. 2022 Dec. 15 [cited 2024 Nov. 22];3(Sup.3):e293. Available from: https://globalacademicnursing.com/index.php/globacadnurs/article/view/272

Abstract

The aim was to demonstrate the available evidence on ozone therapy in patients with COVID-19 and its therapeutic applicability through hospital protocols. This is an integrative review, carried out in PubMed and LILACS search sources, from 2011 to 2021. 87 articles were identified, but 11 articles were selected that suited the studied theme. The literature studied indicated that ozone exerts antiviral activity by inhibiting viral replication and direct inactivation of viruses. It is also an adjuvant to antiviral drugs. Combined treatment with ozone and antivirals has been shown to reduce inflammation and lung damage. The routes of ozone administration were systemic (rectal) and autohemotherapy. Conclusions: Ozone therapy is an adjuvant therapy to antiviral treatment in COVID-19-positive patients, in addition to being economically viable and easy to administer.

https://doi.org/10.5935/2675-5602.20200293
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References

Schwartz DA, Graham AL. Potential maternal and infant outcomes from coronavirus 2019-nCoV (SARS-CoV-2) infecting pregnant women: lessons from SARS, MERS, and other human coronavirus infections. Viruses. 2020; 12(2): 194-210. https://doi.org//10.3390/v12020194.

Velavan TP, Meyer CG. The COVID-19 epidemic. Trop Med Int Health. 2020; 25(3): 278‐280. https://doi.org/10.1111/tmi.13383.

Ranaldi GT, Villani ER, Franza L. Rationale for ozone-therapy as an adjuvant therapy in COVID-19: a narrative review. Med Gas Res. 2020; 10(3): 134-138. https://doi.org/10.4103/2045-9912.289462.

Bhimraj A, Morgan R, Shumaker AH, Lavergne V, Baden L, Cheng VCC, et al. Infectious diseases society of america guidelines on the treatment and management of patients with COVID-19. CID. 2020; ciaa478. https://doi.org/10.1093/cid/ciaa478.

Hernández A, Viñals M, Pablos A, Vilás F, Papadakos PJ, Wijeysundera DN, et al. Ozone therapy for patients with COVID-19 pneumonia: Preliminary report of a prospective case-control study. Int Immunopharmacol. 2021; 90: 107261. https://doi.org/10.1016/j.intimp.2020.107261.

Hernández A, Viñals M, Isidoro T, Vilás F. Potential role of oxygen–ozone therapy in treatment of COVID-19 pneumonia. Am J Case Rep. 2020; 21: e925849. https://doi.org/10.12659/AJCR.925849.

Colak S, Yavuz BG, Yavuz M, Ozçelik B, Oner M, Ozgultekin A, et al. Effectiveness of ozone therapy in addition to conventional treatment on mortality in patients with COVID-19. Int J Clin Pract. 2021; 75: e1432. https://doi.org/10.1111/ijcp.14321.

Brasil. Ministério da Saúde. Portaria n° 702, de 21 de março de 2018. Altera a Portaria de consolidação nº 2/GM/MS, de 28 de setembro de 2017, para incluir novas práticas na Política Nacional de Práticas Integrativas e Complementares - PNPIC. Diário Oficial da União. 22 Mar 2018. Citado em 2021 nov. 10. Disponível em: https://bvsms.saude.gov.br/bvs/saudelegis/gm/2018/prt0702_22_03_2018.html.

Brasil. Conselho Federal de Enfermagem (COFEN). Parecer normativo n° 01, de 20 de fevereiro de 2020. Regulamentar a ozonioterapia como prática do enfermeiro no Brasil. Citado em 2021 nov. 13. Disponível em: http://www.cofen.gov.br/wp-content/uploads/2020/02/PARECER-NORMATIVO-01-2020-1.pdf.

Bialoszewski D, Pietruczuk-Padzik A, Kalicinska A, Bocian E, Czajkowska M, Bulowska B, et al. Activity of ozonated water and ozone against Staphylococcus aureus and Pseudomonas aeruginosa biofilms. Med Sci Monit. 2011; 17(11): 339-344. https://doi.org/10.12659/MSM.882044.

Loprete F, Vaiano F. The use of ozonated water and rectal insufflation in patients with intestinal dysbiosis. Ozone Therapy 2017; 2(3): 56-61. https://doi.org/10.4081/ozone.2017.7304.

Franzini M, Valdenassi L, Ricevuti G, Chirumbolo S, Depfenhart M, Bertossi D, et al. Oxygen-ozone (O2-O3) immunoceutical therapy for patients with COVID-19. Preliminary evidence reported. Int Immunopharmacol. 2020; 88: 106879. https://doi.org/10.1016/j.intimp.2020.106879.

Martínez-Sánchez G, Schwartz A, Donna VD. Potential cytoprotective activity of ozone therapy in SARS-CoV-2/COVID-19. Antioxidants (Basel). (2020) 9: 389. https://doi.org/10.3390/antiox9050389.

Valdenassi L, Franzini M, Ricevuti G, Rinaldi L, Galoforo AC, Tirelli U. Potential mechanisms by which the oxygen-ozone (O2-O3) therapy could contribute to the treatment against the coronavirus COVID-19. Eur Rev Med Pharmacol Sci. 2020; 24:4059-61. https://doi.org/10.26355/eurrev_202004_20976.

Moher D, Liberati A, Tetzlaff J, Altman DG, Group P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol. 2009; 62(10): 1006-1012. https://doi.org/10.1136/bmj.m2632.

Rezende PT, Melo VAP, Andrade CMO, Reis TA, Dietrich L. A ozonioterapia como coadjuvante no tratamento em pacientes com COVID-19. Res Soc Dev. 2021; 10(14): e125101421662. http://dx.doi.org/10.33448/rsd-v10i14.21662.

Tascini C, Sermann G., Pagotto A, Sozio E, De Carlo C, Giacinto A, et al. Blood ozonization in patients with mild to moderate COVID 19 pneumonia: a single centre experience. Intern Emerg Med. 16(3): 669-675. https://doi.org/10.1007/s11739-020-02542-6.

Mauro RD, Cantarella G, Bernardini R, Di Rosa M, Barbagallo J, Distefano A, et al. The biochemical and pharmacological properties of ozone: The smell of protection in acute and chronic diseases. Int J Mol Sci. 2019; 20(3): 634. https://doi.org/10.3390/ijms20030634.

Menendez-Cepero S, Marques-Magallanes-Regojo JA, Hernandez Martinez A, Tallón FJH, Baeza-Noci J. Therapeutic effects of Ozone therapy that justifies its use for the treatment of COVID19. Res Open J Neurol. 2020; 3 (1): 1-6. https://doi.org/10.31038/ JNNC.2020314.

Pena-Lora DY, Albaladejo-Florín MJ, Fernández-Cuadros ME. Uso de ozonoterapia rectal en paciente anciana con neumonía grave por COVID-19. Rev Esp Geriatr Gerontol. 2020; 55(6): 362-364. https://doi.org/10.1016/j.regg.2020.07.005.

Wu J, Tan CS, Yu H, Wang Y, Wang Y, Tian Y, et al. Recovery of four COVID-19 patients via ozonated autohemotherapy. The Innovation. 2020; 1: 100060. https://doi.org/10.1016/j.xinn.2020.

Araimo F, Imperiale C, Tordiglione P, Ceccarelli G, Borazzo C, Alessandri F, et al. Ozone as adjuvant support in the treatment of COVID‐19: A preliminary report of probiozovid trial. J Med Virol. 2021; 93: 2210-2220. https://doi.org/10.1002/jmv.26636.

Cattel F, Giordano S, Bertiond C, Lupia T, Corcione S, Scaldaferri M, et al. Ozone therapy in COVID-19: A narrative review. Virus Res. 2021; 291: 198207. https://doi.org/10.1016/j.virusres.2020.198207.

Sozio E, De Monte A, Sermann G, Bassi F, Sacchet D, Sbrana, F, et al. Coronavirus-19 mild to moderate pneumonia Management with blood ozonization in patients with respiratory failure (CORMOR) multicentric prospective randomized clinical trial. Int Immunopharmacol. 2021; 98: 107874. https://doi.org/10.1016/j.intimp.2021.107874.

Shah M, Captain J, Vaidya V, Kulbarni A, Valsangkar K, Nair PMK, et al. Safety and efficacy of ozone therapy in mild to moderate COVID-19 patients: A phase 1/11 randomized control trial (SEOT study). Int Immunopharmacol. 2021; 91: 107301. https://doi.org/10.1016/j.intimp.2020.107301.

Siddiqi HK, Mehra MR. COVID-19 illness in native and immunosuppressed states: a clinical- therapeutic staging proposal. J Heart Lung Transplant. 2020; 39: 405-407. https://doi.org/10.1016/j.healun.2020.03.012

Fernández-Cuadros ME, Albaladejo-Florín MJ, Álava-Rabasa S, Gallego-Galiana J, Pérez-Cruz GF, Usandizaga-Elio I, et al. Compassionate use of rectal ozone (O3) in severe COVID-19 pneumonia: A case-control study. SN Compr Clin Med. 2021; 22: 1-15. https://doi.org/10.1007/s42399-021-00849-9.

Williamson B N, Feldmann F, Schwarz B, Meade-White K, Porter DP, Schulz J, et al. Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2. Nature. 2020; 585: 273-276. https://doi.org/10.1038/s41586-020-2423-5.

Monteiro IC, Prudente ALN, Carneiro JF, Gomes JM, Mariano HMP, Silvério AO. Manifestações hepáticas em pacientes com covid‐19: Uma revisão integrativa. Braz J Infect Dis. 2021; 25: 101138. https://doi.org/10.1016/j.bjid.2020.101138.

Galicia GC, Santana HGP, Vega SE. Asociación de ferritina con deterioro ventilatorio y mortalidad debido a COVID-19 en terapia intensiva. Med Crit. 2021; 35(3): 121-129. https://doi.org/10.35366/100000.

Brasil. Ministério da Saúde. Secretaria de ciência, tecnologia, inovação e insumos estratégicos em saúde. Diretrizes para diagnóstico e tratamento da COVID-19. Brasília: Ministério da Saúde, 2020. Citado em 2021 nov. 15. Disponível em: https://sbim.org.br/images/files/notas-tecnicas/ddt-covid-19-200407.pdf.

Valdenassi L, Franzini M, Simonetti V, Ricevuti G. Oxygen-ozone therapy: paradoxical stimulation of ozone. Ozone Therapy. 2016; 1(1): 2-4. https://doi.org/10.4081/ozone.2016.5837.

Sancak EB, Turkön H, Çukur S, Erimasah S, Akbas A, Gulpinar MT, et al. Major ozonated autohemotherapy preconditioning ameliorates kidney ischemia-reperfusion injury. Inflammation, 2016; 39(1): 209-217. https://doi.org/ 10.1007/s10753-015-0240-z.

Paulesu L, Luzzi E, Bocci V. Studies on the biological effects of ozone: 2. Induction of tumor necrosis factor (TNF-alpha) on human leucocytes. Lymphokine Cytokine Res. 1991; 10 (5): 409-412. https://pubmed.ncbi.nlm.nih.gov/1768744/.

Frush BW, Zhuowei L, Stiles JV, Cotter SF, Shofer SL, Foster WM, et al. Ozone primes alveolar macrophage-derived innate immunity in healthy human subjects. J Allergy Clin Immu. 2016; 138 (4): 1213-1215. https://doi.org/10.1016/j.jaci.2016.03.052.

Paula KJS, Urruchi WMI, Freire MHS. Determinação da concentração de ozônio em diferentes tipos de soluções aquosas para uso na prática clínica. Glob Acad Nurs. 2021;2(1):e64. https://dx.doi.org/10.5935/2675-5602.20200064

Zuo T, Zhang F, Lui GCY, Yeoh YK, Li AYL, Zhan H, et al. Alterations in gut microbiota of patients with COVID‐19 during time of hospitalization. Gastroenterology. 2020; 20: 34701‐34706. https://doi.org/10.1053/j. gastro.2020.05.048.

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