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Ozonioterapia na COVID-19: uma revisão integrativa
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Palavras-chave

Doença pelo Novo Coronavírus (2019-nCoV)
Ozônio
Infecção pelo SARS-CoV-2
Infecção Viral COVID-19
Sistema Imunológico

Como Citar

1.
Jurado SR, Paiz C dos S, Bispo IMGP, Furlan MCR, Bassler TC, Sanchez A. Ozonioterapia na COVID-19: uma revisão integrativa. Glob Acad Nurs [Internet]. 15º de dezembro de 2022 [citado 22º de novembro de 2024];3(Sup.3):e293. Disponível em: https://globalacademicnursing.com/index.php/globacadnurs/article/view/272

Resumo

Objetivou-se demonstrar as evidências disponíveis sobre ozonioterapia em pacientes com COVID-19 e sua aplicabilidade terapêutica por meio de protocolos hospitalares. Trata-se de uma revisão integrativa, realizada nas fontes de busca PubMed e LILACS, no período de 2011 a 2021. Foram identificados 87 artigos, mas, selecionados 11 artigos que se adequaram à temática estudada. A literatura estudada apontou que o ozônio exerce atividade antiviral por meio da inibição da replicação viral e da inativação direta dos vírus. Também é um adjuvante às drogas antivirais. O tratamento combinado com ozônio e os antivirais demonstrou redução da inflamação e dos danos pulmonares. As vias de administração do ozônio foram sistêmica (retal) e auto-hemoterapia. Conclusões: A ozonioterapia é uma terapia adjuvante ao tratamento com antivirais em pacientes COVID-19-positivos, além de ser viável economicamente e de fácil administração.

https://doi.org/10.5935/2675-5602.20200293
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Referências

Schwartz DA, Graham AL. Potential maternal and infant outcomes from coronavirus 2019-nCoV (SARS-CoV-2) infecting pregnant women: lessons from SARS, MERS, and other human coronavirus infections. Viruses. 2020; 12(2): 194-210. https://doi.org//10.3390/v12020194.

Velavan TP, Meyer CG. The COVID-19 epidemic. Trop Med Int Health. 2020; 25(3): 278‐280. https://doi.org/10.1111/tmi.13383.

Ranaldi GT, Villani ER, Franza L. Rationale for ozone-therapy as an adjuvant therapy in COVID-19: a narrative review. Med Gas Res. 2020; 10(3): 134-138. https://doi.org/10.4103/2045-9912.289462.

Bhimraj A, Morgan R, Shumaker AH, Lavergne V, Baden L, Cheng VCC, et al. Infectious diseases society of america guidelines on the treatment and management of patients with COVID-19. CID. 2020; ciaa478. https://doi.org/10.1093/cid/ciaa478.

Hernández A, Viñals M, Pablos A, Vilás F, Papadakos PJ, Wijeysundera DN, et al. Ozone therapy for patients with COVID-19 pneumonia: Preliminary report of a prospective case-control study. Int Immunopharmacol. 2021; 90: 107261. https://doi.org/10.1016/j.intimp.2020.107261.

Hernández A, Viñals M, Isidoro T, Vilás F. Potential role of oxygen–ozone therapy in treatment of COVID-19 pneumonia. Am J Case Rep. 2020; 21: e925849. https://doi.org/10.12659/AJCR.925849.

Colak S, Yavuz BG, Yavuz M, Ozçelik B, Oner M, Ozgultekin A, et al. Effectiveness of ozone therapy in addition to conventional treatment on mortality in patients with COVID-19. Int J Clin Pract. 2021; 75: e1432. https://doi.org/10.1111/ijcp.14321.

Brasil. Ministério da Saúde. Portaria n° 702, de 21 de março de 2018. Altera a Portaria de consolidação nº 2/GM/MS, de 28 de setembro de 2017, para incluir novas práticas na Política Nacional de Práticas Integrativas e Complementares - PNPIC. Diário Oficial da União. 22 Mar 2018. Citado em 2021 nov. 10. Disponível em: https://bvsms.saude.gov.br/bvs/saudelegis/gm/2018/prt0702_22_03_2018.html.

Brasil. Conselho Federal de Enfermagem (COFEN). Parecer normativo n° 01, de 20 de fevereiro de 2020. Regulamentar a ozonioterapia como prática do enfermeiro no Brasil. Citado em 2021 nov. 13. Disponível em: http://www.cofen.gov.br/wp-content/uploads/2020/02/PARECER-NORMATIVO-01-2020-1.pdf.

Bialoszewski D, Pietruczuk-Padzik A, Kalicinska A, Bocian E, Czajkowska M, Bulowska B, et al. Activity of ozonated water and ozone against Staphylococcus aureus and Pseudomonas aeruginosa biofilms. Med Sci Monit. 2011; 17(11): 339-344. https://doi.org/10.12659/MSM.882044.

Loprete F, Vaiano F. The use of ozonated water and rectal insufflation in patients with intestinal dysbiosis. Ozone Therapy 2017; 2(3): 56-61. https://doi.org/10.4081/ozone.2017.7304.

Franzini M, Valdenassi L, Ricevuti G, Chirumbolo S, Depfenhart M, Bertossi D, et al. Oxygen-ozone (O2-O3) immunoceutical therapy for patients with COVID-19. Preliminary evidence reported. Int Immunopharmacol. 2020; 88: 106879. https://doi.org/10.1016/j.intimp.2020.106879.

Martínez-Sánchez G, Schwartz A, Donna VD. Potential cytoprotective activity of ozone therapy in SARS-CoV-2/COVID-19. Antioxidants (Basel). (2020) 9: 389. https://doi.org/10.3390/antiox9050389.

Valdenassi L, Franzini M, Ricevuti G, Rinaldi L, Galoforo AC, Tirelli U. Potential mechanisms by which the oxygen-ozone (O2-O3) therapy could contribute to the treatment against the coronavirus COVID-19. Eur Rev Med Pharmacol Sci. 2020; 24:4059-61. https://doi.org/10.26355/eurrev_202004_20976.

Moher D, Liberati A, Tetzlaff J, Altman DG, Group P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol. 2009; 62(10): 1006-1012. https://doi.org/10.1136/bmj.m2632.

Rezende PT, Melo VAP, Andrade CMO, Reis TA, Dietrich L. A ozonioterapia como coadjuvante no tratamento em pacientes com COVID-19. Res Soc Dev. 2021; 10(14): e125101421662. http://dx.doi.org/10.33448/rsd-v10i14.21662.

Tascini C, Sermann G., Pagotto A, Sozio E, De Carlo C, Giacinto A, et al. Blood ozonization in patients with mild to moderate COVID 19 pneumonia: a single centre experience. Intern Emerg Med. 16(3): 669-675. https://doi.org/10.1007/s11739-020-02542-6.

Mauro RD, Cantarella G, Bernardini R, Di Rosa M, Barbagallo J, Distefano A, et al. The biochemical and pharmacological properties of ozone: The smell of protection in acute and chronic diseases. Int J Mol Sci. 2019; 20(3): 634. https://doi.org/10.3390/ijms20030634.

Menendez-Cepero S, Marques-Magallanes-Regojo JA, Hernandez Martinez A, Tallón FJH, Baeza-Noci J. Therapeutic effects of Ozone therapy that justifies its use for the treatment of COVID19. Res Open J Neurol. 2020; 3 (1): 1-6. https://doi.org/10.31038/ JNNC.2020314.

Pena-Lora DY, Albaladejo-Florín MJ, Fernández-Cuadros ME. Uso de ozonoterapia rectal en paciente anciana con neumonía grave por COVID-19. Rev Esp Geriatr Gerontol. 2020; 55(6): 362-364. https://doi.org/10.1016/j.regg.2020.07.005.

Wu J, Tan CS, Yu H, Wang Y, Wang Y, Tian Y, et al. Recovery of four COVID-19 patients via ozonated autohemotherapy. The Innovation. 2020; 1: 100060. https://doi.org/10.1016/j.xinn.2020.

Araimo F, Imperiale C, Tordiglione P, Ceccarelli G, Borazzo C, Alessandri F, et al. Ozone as adjuvant support in the treatment of COVID‐19: A preliminary report of probiozovid trial. J Med Virol. 2021; 93: 2210-2220. https://doi.org/10.1002/jmv.26636.

Cattel F, Giordano S, Bertiond C, Lupia T, Corcione S, Scaldaferri M, et al. Ozone therapy in COVID-19: A narrative review. Virus Res. 2021; 291: 198207. https://doi.org/10.1016/j.virusres.2020.198207.

Sozio E, De Monte A, Sermann G, Bassi F, Sacchet D, Sbrana, F, et al. Coronavirus-19 mild to moderate pneumonia Management with blood ozonization in patients with respiratory failure (CORMOR) multicentric prospective randomized clinical trial. Int Immunopharmacol. 2021; 98: 107874. https://doi.org/10.1016/j.intimp.2021.107874.

Shah M, Captain J, Vaidya V, Kulbarni A, Valsangkar K, Nair PMK, et al. Safety and efficacy of ozone therapy in mild to moderate COVID-19 patients: A phase 1/11 randomized control trial (SEOT study). Int Immunopharmacol. 2021; 91: 107301. https://doi.org/10.1016/j.intimp.2020.107301.

Siddiqi HK, Mehra MR. COVID-19 illness in native and immunosuppressed states: a clinical- therapeutic staging proposal. J Heart Lung Transplant. 2020; 39: 405-407. https://doi.org/10.1016/j.healun.2020.03.012

Fernández-Cuadros ME, Albaladejo-Florín MJ, Álava-Rabasa S, Gallego-Galiana J, Pérez-Cruz GF, Usandizaga-Elio I, et al. Compassionate use of rectal ozone (O3) in severe COVID-19 pneumonia: A case-control study. SN Compr Clin Med. 2021; 22: 1-15. https://doi.org/10.1007/s42399-021-00849-9.

Williamson B N, Feldmann F, Schwarz B, Meade-White K, Porter DP, Schulz J, et al. Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2. Nature. 2020; 585: 273-276. https://doi.org/10.1038/s41586-020-2423-5.

Monteiro IC, Prudente ALN, Carneiro JF, Gomes JM, Mariano HMP, Silvério AO. Manifestações hepáticas em pacientes com covid‐19: Uma revisão integrativa. Braz J Infect Dis. 2021; 25: 101138. https://doi.org/10.1016/j.bjid.2020.101138.

Galicia GC, Santana HGP, Vega SE. Asociación de ferritina con deterioro ventilatorio y mortalidad debido a COVID-19 en terapia intensiva. Med Crit. 2021; 35(3): 121-129. https://doi.org/10.35366/100000.

Brasil. Ministério da Saúde. Secretaria de ciência, tecnologia, inovação e insumos estratégicos em saúde. Diretrizes para diagnóstico e tratamento da COVID-19. Brasília: Ministério da Saúde, 2020. Citado em 2021 nov. 15. Disponível em: https://sbim.org.br/images/files/notas-tecnicas/ddt-covid-19-200407.pdf.

Valdenassi L, Franzini M, Simonetti V, Ricevuti G. Oxygen-ozone therapy: paradoxical stimulation of ozone. Ozone Therapy. 2016; 1(1): 2-4. https://doi.org/10.4081/ozone.2016.5837.

Sancak EB, Turkön H, Çukur S, Erimasah S, Akbas A, Gulpinar MT, et al. Major ozonated autohemotherapy preconditioning ameliorates kidney ischemia-reperfusion injury. Inflammation, 2016; 39(1): 209-217. https://doi.org/ 10.1007/s10753-015-0240-z.

Paulesu L, Luzzi E, Bocci V. Studies on the biological effects of ozone: 2. Induction of tumor necrosis factor (TNF-alpha) on human leucocytes. Lymphokine Cytokine Res. 1991; 10 (5): 409-412. https://pubmed.ncbi.nlm.nih.gov/1768744/.

Frush BW, Zhuowei L, Stiles JV, Cotter SF, Shofer SL, Foster WM, et al. Ozone primes alveolar macrophage-derived innate immunity in healthy human subjects. J Allergy Clin Immu. 2016; 138 (4): 1213-1215. https://doi.org/10.1016/j.jaci.2016.03.052.

Paula KJS, Urruchi WMI, Freire MHS. Determinação da concentração de ozônio em diferentes tipos de soluções aquosas para uso na prática clínica. Glob Acad Nurs. 2021;2(1):e64. https://dx.doi.org/10.5935/2675-5602.20200064

Zuo T, Zhang F, Lui GCY, Yeoh YK, Li AYL, Zhan H, et al. Alterations in gut microbiota of patients with COVID‐19 during time of hospitalization. Gastroenterology. 2020; 20: 34701‐34706. https://doi.org/10.1053/j. gastro.2020.05.048.

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